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[Transgenerational transmission mediated by small non-coding RNA in sperm].
Xuan Zhou1, Xiao Shi1, Song Quan1
1Center of Reproductive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Zhonghua Nan Ke Xue = National Journal of Andrology
|December 28, 2017
Summary
Mature human sperm contain RNA, influencing early embryo development. Environmental factors like diet and stress alter small non-coding RNAs, impacting offspring development and transgenerational inheritance.
Area of Science:
- Reproductive Biology
- Epigenetics
- Molecular Biology
Background:
- Mature human sperm contain RNA, influencing early embryonic development.
- Environmental exposures, such as diet and stress, can alter small non-coding RNA expression in sperm.
- Small non-coding RNAs act as carriers of paternal information and epigenetic markers.
Purpose of the Study:
- To review new findings on transgenerational epigenetics related to sperm small non-coding RNAs.
- To explore the role of sperm piRNA, microRNA, and tRNA in mediating transgenerational transmission.
- To offer novel insights into male reproduction and its epigenetic regulation.
Main Methods:
- Literature review of recent studies on sperm RNA and epigenetics.
- Analysis of mechanisms by which small non-coding RNAs mediate transgenerational effects.
- Focus on sperm-derived PIWI-interacting RNAs (piRNAs), microRNAs (miRNAs), and transfer RNAs (tRNAs).
Main Results:
- Small non-coding RNAs in sperm are crucial for early embryo development and offspring outcomes.
- Environmental factors can modify sperm small non-coding RNA profiles, leading to epigenetic alterations.
- Sperm piRNAs, miRNAs, and tRNAs are key mediators of transgenerational epigenetic inheritance.
Conclusions:
- Sperm small non-coding RNAs represent a significant target for understanding male reproductive epigenetics.
- Transgenerational epigenetic transmission via sperm RNA impacts offspring development.
- Further research into sperm RNA is essential for novel male reproductive strategies.
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