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Fenofibrate-Induced Lichenoid Drug Eruption: A Rare Culprit.

Fayeza Mohammed¹, Laura L Wally¹, Jeffrey E Karaban²

¹Department of Family Medicine, Presence Saint Joseph Hospital, Chicago, Illinois, USA.

Case Reports in Dermatology

|December 29, 2017

Summary

Fenofibrate can cause a rare lichenoid drug eruption, a significant dermatologic side effect. A potential familial link suggests genetic factors may influence these reactions.

Keywords:

Drug eruption Fenofibrate Lichenoid Photosensitivity Rash

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Area of Science:

Dermatology
Pharmacology
Genetics

Background:

Lichenoid drug eruptions are uncommon adverse reactions to various medications.
Identifying the causative agent is crucial for managing these dermatologic conditions.

Observation:

This report details a unique case where fenofibrate was identified as the cause of a lichenoid drug eruption.
The case also suggests a possible familial predisposition to this adverse reaction.

Findings:

Fenofibrate is a potential causative agent for lichenoid drug eruptions.
Genetic factors may play a role in the development of lichenoid drug eruptions, as indicated by a potential familial association.

Implications:

This finding highlights a rare but clinically significant dermatologic side effect of fenofibrate.
Understanding the characteristics of lichen planus, medication timing, UV exposure effects, and symptom persistence is key for diagnosis and treatment.
Further research into genetic mechanisms could improve the prediction and prevention of drug-induced lichenoid eruptions.