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Updated: Feb 16, 2026

A Time Differential Staining Technique Coupled with Full Bilateral Gill Denervation to Study Ionocytes in Fish
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Amiodarone-associated bilateral vestibulopathy.

Robert Gürkov1, Leonardo Manzari2, Alexander Blödow3

  • 1Department of Otorhinolaryngology, LMU Munich, Munich, Germany. robert.guerkov@med.uni-muenchen.de.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|December 29, 2017
PubMed
Summary

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Articles linked to this work by shared authors, journal, and citation graph.

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Same author

Persistent Dizziness and Time-Domain Dissociation in Vestibular Function: A Hypothesis-Generating Case Series and Spatiotemporal Framework for Targeted Vestibular Rehabilitation.

Healthcare (Basel, Switzerland)·2026
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High-frequency pseudo-hypofunction of the superior semicircular canal dehiscence syndrome: a vHIT - oVEMP dissociation explained by hydrodynamic energy loss.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
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Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie·2026
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Velocity Storage Integrator (VSI): Mechanisms, circuits, and clinical implications A narrative review.

American journal of otolaryngology·2026
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Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie·2026
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Multiscale Integration of Acceleration and Jerk Sensing in the Vestibular System.

Audiology research·2026

Amiodarone may cause bilateral vestibulopathy (BVP), a balance disorder. This study found a 12% prevalence of BVP in patients with a history of Amiodarone treatment, suggesting a link.

Area of Science:

  • Neurology
  • Ophthalmology
  • Otolaryngology

Background:

  • Bilateral vestibulopathy (BVP) is a disabling condition resulting from impaired vestibular organs.
  • Common causes include ototoxic drugs, infections, and autoimmune diseases, but many cases are idiopathic.

Purpose of the Study:

  • To investigate the potential link between Amiodarone use and idiopathic bilateral vestibulopathy.
  • To determine the prevalence of prior Amiodarone treatment in patients diagnosed with idiopathic BVP.

Main Methods:

  • Retrospective analysis of medical records from five dizziness clinics.
  • Identification of patients diagnosed with idiopathic BVP.

Main Results:

  • 126 patients with idiopathic BVP were identified.
Keywords:
AmiodaroneBilateral vestibulopathyNeurotoxicityOtotoxicity

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  • A 12% prevalence of BVP was observed in patients with a history of Amiodarone treatment (15 out of 126).

    • Conclusions:

    • The findings support the hypothesis that Amiodarone can induce bilateral vestibulopathy.
    • Recommends vestibular examination for patients on Amiodarone experiencing balance issues to enable early intervention.