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Updated: Feb 16, 2026

Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs
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miR-155 in cancer drug resistance and as target for miRNA-based therapeutics

Recep Bayraktar1, Katrien Van Roosbroeck2

  • 1Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1881 Holcombe Boulevard, Unit 1950, Houston, TX, 77054, USA.

Cancer Metastasis Reviews
|December 29, 2017
PubMed

Insights

MicroRNAs (miRNAs) regulate cell processes, with miR-155 linked to cancer and therapy resistance. Targeting miR-155 offers potential for novel cancer treatments.

Area of Science:

  • Molecular Biology
  • Oncology
  • Immunology

Background:

  • MicroRNAs (miRNAs) are key regulators of cellular functions, including proliferation and apoptosis.
  • Dysregulated miRNA expression is implicated in various diseases, notably cancer.
  • miR-155 is a conserved, multifunctional miRNA frequently overexpressed in malignant tumors.

Purpose of the Study:

  • To review the role of miR-155 in hematopoietic differentiation, immune response, and inflammation.
  • To explore miR-155's involvement in cancer therapy resistance.
  • To discuss the therapeutic potential of targeting miR-155 in cancer treatment.

Main Methods:

  • Literature review of studies on miR-155 function and its clinical relevance.
  • Analysis of miR-155's impact on cellular processes and disease pathogenesis.
  • Synthesis of current knowledge on miR-155-mediated signaling pathways.

Main Results:

  • miR-155 is associated with hematopoietic lineage differentiation, immune regulation, and inflammatory processes.
  • Overexpression of miR-155 contributes to tumorigenesis and drives therapy resistance in various cancers.
  • miR-155 plays a significant role in the complex interplay between immunity, inflammation, and cancer development.

Conclusions:

  • miR-155 is a critical regulator in physiological and pathological processes, particularly in cancer.
  • Understanding miR-155's functions is crucial for developing targeted cancer therapies.
  • miR-155-based strategies hold promise for overcoming cancer therapy resistance and improving patient outcomes.
Keywords:
CancerChemoresistanceRadioresistanceTherapymiR-155miRNAoncomiR

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