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Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia

Fady M El Gendy1, Mahmoud A El-Hawy1, Amira M F Shehata2

  • 1Pediatrics Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Menoufia, Egypt.

European Journal of Haematology
|December 29, 2017
PubMed

Insights

Serum erythroferrone (ERFE) levels are significantly higher in children with iron deficiency anemia. ERFE may suppress hepcidin, offering a potential therapeutic target for anemia.

Area of Science:

  • Pediatric Hematology
  • Iron Metabolism
  • Hormonal Regulation

Background:

  • Iron deficiency anemia (IDA) is a prevalent condition in children.
  • Erythroferrone (ERFE) is a recently identified hormone involved in iron regulation.
  • Understanding ERFE's role in IDA is crucial for developing new therapies.

Purpose of the Study:

  • To investigate the association between serum ERFE levels and iron status in pediatric IDA.
  • To explore the correlation of ERFE with key iron parameters like hemoglobin, ferritin, serum iron, transferrin saturation, and TIBC.

Main Methods:

  • A cohort of 66 children, including 36 with IDA and 30 healthy controls, was studied.
  • Serum levels of iron, total iron-binding capacity (TIBC), ferritin, and ERFE were measured.
  • Standard automated chemistry analyzers, electrochemiluminescence immunoassay, and ELISA kits were utilized.

Main Results:

  • Children with IDA exhibited significantly higher serum ERFE levels compared to controls (191.55 ± 83.74 pg/mL vs. 42.22 ± 16.55 pg/mL, P < .001).
  • In IDA patients, ERFE levels negatively correlated with hemoglobin, serum iron, transferrin saturation, and ferritin.
  • A positive correlation was found between ERFE and TIBC in IDA patients (r = .62, P < .001).

Conclusions:

  • Elevated serum ERFE in pediatric IDA suggests a potential role in iron dysregulation.
  • ERFE may function as a physiological suppressor of hepcidin in IDA.
  • ERFE presents a promising therapeutic target for managing iron deficiency anemia.
Abstract

Keywords:
erythroblastserythroferroneferritinhepcidiniron deficiency anemia

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