Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Deformation of Member under Multiple Loadings01:11

Deformation of Member under Multiple Loadings

497
When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
497
Design of Columns under a Centric Load01:17

Design of Columns under a Centric Load

579
The design of columns under centric load is a fundamental aspect of structural engineering and is critical for ensuring the stability and integrity of structures. Euler's and Secant's formulas are central to understanding and calculating the critical load and deformation behaviors of columns, providing a basis for safe and effective structural design.
Euler's formula is applicable under the assumption that the column is a perfect, straight, homogenous prism, and it is operating...
579
Design of Columns under an Eccentric Load01:21

Design of Columns under an Eccentric Load

1.2K
Designing columns to withstand eccentric loads is a critical aspect of structural engineering, ensuring structures can support off-center loads without failure. This design process must account for the additional normal stresses introduced by eccentric loading, which can significantly influence a column's stress distribution and overall stability. An eccentric load applied to a column induces normal stresses that can be conceptualized as a combination of stresses due to an equivalent...
1.2K
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

268
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
268
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

255
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
255
Group Design02:01

Group Design

10.8K
The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...
10.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulating pre-diagnostic metabolites and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: a population-based study of 12 cohorts.

Journal of the National Cancer Institute·2026
Same author

<i>In situ</i> self-catalyzed growth of Ni-N co-doped carbon nanotubes on carbon foam with engineered heterointerfaces for efficient electromagnetic absorption and stealth performance.

Nanoscale·2026
Same author

Summary of best evidence on fall interventions for older adults with dementia in long-term care institutions.

Geriatric nursing (New York, N.Y.)·2026
Same author

A molybdenum-promoted nickel-aluminum alloy catalyst for high-efficient hydrogenation reduction of nitrate to ammonia and nitrogen.

RSC advances·2026
Same author

Increased serum phenylalanine and tyrosine concentration related to inflammation in patients with primary angiitis of the central nervous system.

Biochemistry and biophysics reports·2026
Same author

Effects of a family-centered empowerment intervention on role adaptation and depressive symptoms in high-risk primigravidas and their partners.

BMC pregnancy and childbirth·2026

Related Experiment Video

Updated: Feb 16, 2026

Standardized Modular Assembly of Polycistronic Operons with Modular Cloning (MoClo) using the In-Cloning toolkit
06:28

Standardized Modular Assembly of Polycistronic Operons with Modular Cloning (MoClo) using the In-Cloning toolkit

Published on: September 2, 2025

869

A Modularly Designable Vesicle for Sequentially Multiple Loading.

Yiyang Zhang1, Dandan Bao2, Shuo Wang1

  • 1Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.

Small (Weinheim an Der Bergstrasse, Germany)
|December 29, 2017
PubMed
Summary

This study introduces a novel modular vesicle platform for sequential multiple drug loading, overcoming challenges in co-delivering diverse therapeutic agents for enhanced cancer therapy.

Keywords:
drug deliverymodular designedmultiloadingvesicles

More Related Videos

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

13.0K
The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy
11:53

The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy

Published on: October 14, 2017

12.3K

Related Experiment Videos

Last Updated: Feb 16, 2026

Standardized Modular Assembly of Polycistronic Operons with Modular Cloning (MoClo) using the In-Cloning toolkit
06:28

Standardized Modular Assembly of Polycistronic Operons with Modular Cloning (MoClo) using the In-Cloning toolkit

Published on: September 2, 2025

869
Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

13.0K
The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy
11:53

The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy

Published on: October 14, 2017

12.3K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Vesicles are promising drug delivery platforms, with materials like lipids and polymers explored for enhanced drug efficacy.
  • Current research focuses on stimuli-responsive features, stability enhancements (crosslinking, pegylation), and targeting ligands.
  • Multidrug delivery offers synergistic effects in cancer therapy, but efficient co-loading of diverse molecules remains a challenge.

Purpose of the Study:

  • To develop a modularly designable vesicle for sequential multiple loading.
  • To address the challenge of efficiently co-loading hydrophilic-hydrophobic small molecules, oligonucleotides, and peptides.
  • To establish a novel platform for advanced drug delivery applications.

Main Methods:

  • Frame-guided assembly for vesicle construction.
  • Modular design enabling sequential loading of different cargo types.
  • Characterization of size- and shape-controlled vesicles with high loading efficiency.

Main Results:

  • Demonstration of a modular vesicle platform capable of sequential multiple loading.
  • Successful co-loading of hydrophilic-hydrophobic small molecules, oligonucleotides, and peptides.
  • Vesicles exhibit controlled size and shape, facilitating efficient drug delivery.

Conclusions:

  • The reported modular vesicle platform offers a breakthrough for complex multidrug delivery.
  • This frame-guided assembly approach provides an outstanding solution for future drug delivery systems.
  • The platform holds significant potential for synergistic cancer therapy and other advanced biomedical applications.