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A Perspective on Proteomics of Infectious Diseases
Apoorva Venkatesh1, Concha Gil2, Manuel Fuentes3,4
1Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.
Proteomics. Clinical Applications
|December 29, 2017
Summary
Proteomics offers a deeper understanding of infectious diseases by analyzing proteins, the functional molecules of cells. This approach, including the Human Infectious Diseases project, addresses knowledge gaps beyond genomics.
Area of Science:
- Infectious disease research
- Proteomics
- Molecular biology
Background:
- Infectious diseases pose a significant global health burden, impacting populations worldwide.
- Genomic data has limitations in fully explaining disease pathogenesis due to post-translational modifications and variable mRNA translation.
- A knowledge gap exists in understanding the molecular basis of infectious diseases.
Purpose of the Study:
- To highlight the applications of proteomics-based approaches in studying infectious diseases.
- To introduce the objectives of the Human Proteome Project (HPP)-Human Infectious Diseases (HID) project.
- To emphasize the importance of studying proteins as functional molecules in disease.
Main Methods:
- Application of proteomics-based strategies.
- Analysis of protein expression, isoforms, and post-translational modifications.
- Leveraging genomic and proteomic data integration.
Main Results:
- Proteins, not just genes, are crucial for understanding cellular function and disease states.
- Proteomics provides insights into molecular alterations during infectious diseases.
- The HPP-HID project aims to advance infectious disease research through proteome analysis.
Conclusions:
- Proteomics is essential for a comprehensive understanding of infectious disease mechanisms.
- Studying the proteome complements genomic information for disease research.
- The HPP-HID project is vital for advancing the molecular understanding of infectious diseases.
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