Use of Promogran to treat venous leg ulcers

Based on the outcome of a series of symposia, this series aims to answer the question, 'what is compromised wound healing and how do we increase our understanding of chronic wounds?' Ultimately, we hope to explore the feasibility of developing a chronicity predictor. Many venous leg ulcers fail to heal when treated with compression and dressings that simply create a moist wound environment. Promogran is designed not only to produce a moist wound environment but also to inhibit protease activity, counteract a pro-oxidant environment, protect growth factors and modulate fibroblast activity. In two case reports concerning hard-to-heal venous leg ulcers, use of Promogran resulted in reduced exudation and stimulation of healing. Clinical observations found with these ulcers were consistent with Promogran's proposed mode of action.