Thrombolytic Therapy in the Current ERA: Myocardial Infarction and Beyond

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Patrick Proctor1, Massoud A Leesar1, Arka Chatterjee1

  • 1Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, United States.

Current Pharmaceutical Design
|December 29, 2017
PubMed

Insights

Thrombolytic therapy, crucial in cardiology, remains vital for acute myocardial infarction and ischemic stroke patients lacking percutaneous coronary intervention (PCI) access. Its evolving applications are explored.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Thrombolytic therapy initiated modern cardiology.
  • Primary percutaneous coronary intervention (PCI) now dominates acute myocardial infarction treatment.
  • Thrombolytics remain essential for patients without PCI access and for acute ischemic stroke.

Purpose of the Study:

  • To review the history and evidence base of thrombolytic agents.
  • To summarize current applications of thrombolytics in cardiovascular disease.
  • To highlight innovative uses of thrombolytic therapy.

Main Methods:

  • Literature review of thrombolytic therapy in cardiovascular disease.
  • Analysis of historical evidence and current clinical practice.
  • Exploration of emerging therapeutic uses.

Main Results:

  • Thrombolytic therapy has a significant historical impact on cardiology.
  • Despite PCI advancements, thrombolytics retain importance for specific patient groups.
  • Novel applications for thrombolytics are emerging.

Conclusions:

  • Thrombolytic agents continue to play a critical role in cardiovascular medicine.
  • Understanding the evidence base and evolving uses of thrombolytics is crucial.
  • Thrombolytics offer therapeutic options for underserved populations and new conditions.

Keywords:
Thrombolysisacute ischemic strokeacute myocardial infarctioncatheter directed thrombolysispulmonary embolismthrombolytic therapy.

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