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Related Concept Videos

Accelerators01:17

Accelerators

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Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
The effectiveness of calcium chloride can...
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Average Acceleration01:30

Average Acceleration

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The importance of understanding acceleration spans our day-to-day experiences, as well as the vast reaches of outer space and the tiny world of subatomic physics. In everyday conversation, to accelerate means to speed up. For instance, we are familiar with the acceleration of our car; the harder we apply our foot to the gas pedal, the faster we accelerate. The greater the acceleration, the greater the change in velocity over a given time. Acceleration is widely seen in experimental physics. In...
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Instantaneous Acceleration01:16

Instantaneous Acceleration

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Acceleration is in the direction of the change in velocity, but it is not always in the direction of motion. When an object slows down, its acceleration is opposite to the direction of its motion. Although commonly referred to as deceleration, this causes confusion in our analysis as deceleration is not a vector, and does not point to a specific direction with respect to a coordinate system. Therefore, the term deceleration is not used. For example, when a subway train slows down, it...
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Acceleration Vectors01:30

Acceleration Vectors

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In everyday conversation, accelerating means speeding up. Acceleration is a vector in the same direction as the change in velocity, Δv, therefore the greater the acceleration, the greater the change in velocity over a given time. Since velocity is a vector, it can change in magnitude, direction, or both. Thus acceleration is a change in speed or direction, or both. For example, if a runner traveling at 10 km/h due east slows to a stop, reverses direction, and continues their run at 10 km/h...
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Accelerating Fluids01:17

Accelerating Fluids

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When a fluid is in constant acceleration, the pressure and buoyant force equations are modified. Suppose a beaker is placed in an elevator accelerating upward with a constant acceleration, a. In the beaker, assume there is a thin cylinder of height h with an infinitesimal cross-sectional area, ΔS.
The motion of the liquid within this infinitesimal cylinder is considered to obtain the pressure difference. Three vertical forces act on this liquid:
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Accelerated Curing of Concrete01:25

Accelerated Curing of Concrete

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Accelerating concrete curing is achieved by applying heat and additional moisture. This process accelerates the hydration of the cement, resulting in an earlier strength gain in the concrete. Steam curing is a method wherein the concrete products are either transported through a chamber on a conveyor belt or encased in plastic, allowing steam at atmospheric pressure to circulate freely around them. This process begins with a phase of moist curing that typically lasts between 3 to 5 hours, after...
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Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
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Microbioreactor Systems for Accelerated Bioprocess Development.

Johannes Hemmerich1,2, Stephan Noack1,2, Wolfgang Wiechert3,2

  • 1Forschungszentrum Jülich, Institute of Bio- and Geosciences - Biotechnology (IBG-1), Wilhelm-Johnen Straße 1, 52425, Jülich, Germany.

Biotechnology Journal
|December 29, 2017
PubMed
Summary
This summary is machine-generated.

Microbioreactor (MBR) systems enhance bioprocess development through high-throughput experimentation and advanced monitoring. These systems are crucial for optimizing industrial biotechnology and sustainable bioproduction.

Keywords:
accelerated bioprocess developmentindustrial biotechnology and bioeconomylab automationmicro-scale cultivationquantitative microbial phenotyping

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Area of Science:

  • Biotechnology
  • Bioprocess Engineering

Background:

  • Microbioreactor (MBR) systems offer advanced solutions for bioprocess engineering.
  • They enable high experimental throughput combined with extensive bioprocess monitoring and control.

Purpose of the Study:

  • To review the current state-of-the-art in microbioreactor systems.
  • To highlight their increasing importance in industrial biotechnology.

Main Methods:

  • MBR systems utilize down-scaled stirred tank reactors or shaken microtiter plate devices.
  • They employ optical measurements for non-invasive, online monitoring of biomass, dissolved oxygen, pH, and fluorescence.
  • Integration with liquid handling robots allows for automation and standardization.

Main Results:

  • MBR systems facilitate quantitative strain phenotyping and bioprocess development under relevant conditions.
  • This integration increases the likelihood of identifying optimal producer strains and control strategies.
  • The versatility and monitoring capabilities of MBR systems are key to developing competitive bioproduction processes.

Conclusions:

  • MBR systems are evolving into indispensable tools for modern bioprocess engineering.
  • Their importance in industrial biotechnology is projected to grow significantly in the near future.