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Recent Advances in Extrusion-Based 3D Printing for Biomedical Applications
Jesse K Placone1, Adam J Engler1
1Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego, 2880 Torrey Pines Scenic Drive, La Jolla, CA, 92037, USA.
Advanced Healthcare Materials
|December 29, 2017
Summary
Additive manufacturing, or 3D printing, advances tissue engineering with new materials for cell-laden bioinks and multi-material scaffolds. Material limitations hinder wider adoption, necessitating improved characterization for reproducibility.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Additive Manufacturing
Background:
- 3D printing is increasingly used in tissue engineering.
- Extrusion-based printing utilizes diverse materials, from cell-free to cell-laden bioinks.
- Multi-material printing enables scaffold fabrication for tissue interfaces.
Purpose of the Study:
- To provide an overview of extrusion-based 3D printing in tissue engineering.
- To identify material limitations hindering wider adoption.
- To suggest improvements for the technique.
Main Methods:
- Review of current extrusion-based 3D printing strategies.
- Analysis of material applications in cell-free and cell-laden printing.
- Discussion of multi-material printing for tissue interfaces.
Main Results:
- Significant advancements in 3D printing materials have occurred.
- Material limitations remain a barrier to widespread use.
- Multi-material printing shows promise for complex tissue structures.
Conclusions:
- Further development of 3D printing materials is crucial for tissue engineering.
- Rigorous material characterization is needed before printing.
- Improved characterization will enhance cross-platform utilization and reproducibility.
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