Association between HIF1α 1772 C/T Polymorphism and Breast Cancer Susceptibility: A Systematic Review

Studies have reached conflicting conclusions about the association of the 1772 C/T polymorphism in the hypoxia-inducible factor 1α (HIF1α) gene with breast cancer risk. To address this, we performed a meta-analysis of relevant studies in the included literature. Data were collected from the electronic databases PubMed and EMBase. The association was assessed by determination of the odds ratio (OR) and the corresponding 95% confidence interval (95% CI). A total of seven articles involving 2343 cases and 2246 controls were analyzed in our meta-analysis. Overall, we found no significant association between the HIF1α C1772T polymorphism and breast cancer (TT vs. CC: OR = 1.33, 95% CI = 0.49-3.63; CT vs. CC: OR = 1.07, 95% CI = 0.90-1.27; dominant model: OR = 1.10, 95% CI = 0.93-1.30; recessive model: OR = 1.32, 95% CI = 0.50-3.49). In stratified analysis by ethnic group, a statistically significant association was observed in Asians. Our findings demonstrated that the 1772 C/T polymorphism in the HIF1α gene might be a risk factor for the development of breast cancer in Asians.