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Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
Published on: November 28, 2012
Molecular Mechanisms of UVA-Induced Melanoma
Xiao Pudroma1, Gongsang Duoji2, Mantas Grigalavicius3
1Department of Physics, Tibet University, Lhasa, China.
Abstract:
Cutaneous melanoma is a deadly skin cancer, resulting from malignant transformation of melanocytes. Long-wave ultraviolet radiation (315-400 nm) is able to damage DNA, cause mutations, and induce melanoma. However, the exact mechanisms of UVA-induced cutaneous melanoma remain a matter of debate. In this review, we give a brief characterization of the most important elements in the photobiology of UVA in melanomagenesis.
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