Related Experiment Video
Updated: Feb 16, 2026

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
Published on: September 22, 2017
Effects of Selective Serotonin Reuptake Inhibitors on Macular Ganglion Cell Complex Thickness and Peripapillary
Hande Guclu1, Yasemın Gorgulu2, Vuslat Pelitli Gurlu1
1a Ophthalmology Department , Trakya University of Medicine , Edirne , Turkey.
Purpose:
To evaluate macular ganglion cell complex (GCC) thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in patients treated with SSRIs.
Methods:
The present study included 62 eyes of 31 patients who were using SSRIs and 60 eyes of 30 healthy, age- and gender-matched control subjects. All patients underwent a full ophthalmological examination in which macular thickness, GCC thickness, and peripapillary RNFL thickness were measured using optical coherence tomography (OCT). The Mann-Whitney U test was used to compare the patients' group with the age- and gender-matched control group. Pearson correlation analyses were also performed to assess the relationships between macular thickness, GCC thickness, RNFL thickness, and the duration of SSRI usage.
Results:
The mean duration of SSRI usage was 29.96 ± 27.19 (range 6-120) months. The foveal thickness was 253.48 ± 22.77µm in the patients' group and 266.60 ± 20.64 µm in the control group; the difference between the groups was statistically significant. In addition, the perifoveal GCC thickness in the inferonasal and inferotemporal quadrant were significantly smaller thinner in the patient group (Mann-Whitney U test, p = 0.021and p = 0.013, respectively).
Conclusions:
Our results suggest a relation between SSRIs and decreased retinal GCC thickness and RNFL thickness. Future long-term prospective studies should elucidate the actual effect of SSRIs on GCC and RNFL thickness.
Related Concept Videos
Design Example: Deciding Thickness of Lubricating Fluid in a Shaft
To calculate the required thickness of the lubricant layer, the tangential velocity at the shaft's surface must first be determined. This velocity is calculated by converting the rotational speed to angular velocity...
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Eukaryotic Transcription Inhibitors
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Outer Layers of the Cell Envelope
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

