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Corneal Biomechanical Properties and Central Corneal Thickness in Pediatric Noninfectious Uveitis: A Controlled Study
Emine Sen1, Melike Balikoglu-Yilmaz, Pinar Ozdal
1Department of Ophthalmology (E.S., P.O.), Ulucanlar Eye Education and Research Hospital, University of Health Sciences, Ankara, Turkey; and Department of Ophthalmology (M.B.-Y.), Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey.
Insights
Pediatric noninfectious uveitis lowers corneal resistance factor (CRF) but not corneal hysteresis (CH), intraocular pressure (IOP), or central corneal thickness (CCT) compared to healthy children.
Area of Science:
- Ophthalmology
- Corneal Science
- Pediatric Eye Disease
Background:
- Pediatric noninfectious uveitis is an inflammatory eye condition.
- Understanding its impact on corneal biomechanics is crucial for patient management.
Purpose of the Study:
- To compare corneal biomechanics, intraocular pressure (IOP), and central corneal thickness (CCT) in children with noninfectious uveitis versus healthy controls.
Main Methods:
- Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated IOP (IOPg), corneal-compensated IOP (IOPcc), and CCT were measured.
- 37 patients with pediatric noninfectious uveitis and 36 healthy children were included.
Main Results:
- Pediatric uveitic eyes showed a significantly lower mean CRF compared to controls.
- No significant differences were found in mean CH, IOPg, IOPcc, or CCT between the groups.
- CCT correlated with CH and CRF, but disease duration did not correlate with any measured corneal parameters.
Conclusions:
- Children with noninfectious uveitis exhibit reduced corneal resistance factor (CRF).
- Corneal hysteresis (CH), IOP, and CCT remain similar to healthy children.
- These findings highlight specific biomechanical changes in pediatric uveitis.
Objective:
To compare the corneal biomechanics, intraocular pressure (IOP), and central corneal thickness (CCT) of 37 patients with pediatric noninfectious uveitis with 36 healthy children.
Methods:
Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated and corneal-compensated IOP (IOPg and IOPcc, respectively), and CCT were measured.
Results:
The mean CRF was significantly lower in the pediatric uveitic eyes than controls (9.7±1.9 vs. 10.8±1.5 mm Hg, P=0.009), whereas there was no significant difference for mean CH, IOPg, IOPcc, and CCT between the two groups (10.1±1.9 vs. 10.8±1.7, 12.9±3.3 vs. 13.9±3.1, 13.8±2.8 vs. 13.6±3.2 mm Hg, and 550.7±49.5 vs. 555.1±33.5 μm, respectively, all P>0.05). The CCT values correlated with CH and CRF, with a Pearson correlation of 0.511 and 0.670 (P=0.013 and P<0.001, respectively), whereas disease duration did not correlate with any corneal biomechanics or CCT in pediatric uveitic eyes (all P>0.05).
Conclusions:
Pediatric noninfectious uveitic eyes have lower CRF than controls but the CH, IOPg, IOPcc, and CCT values are similar.
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