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Glomerular Filtration Rate Is Unchanged by Ultramarathon
Wojciech Wołyniec1, Wojciech Ratkowski, Katarzyna Kasprowicz2
1Department of Occupational, Metabolic and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.
Journal of Strength and Conditioning Research
|December 29, 2017
Summary
Ultramarathon running did not decrease kidney function, despite some runners meeting acute kidney injury (AKI) criteria. Creatinine clearance remained stable, suggesting long-distance running is not harmful to kidney health.
Area of Science:
- Sports Medicine
- Nephrology
- Exercise Physiology
Background:
- Acute kidney injury (AKI) is a known complication of endurance running.
- Previous studies often diagnosed AKI using serum creatinine and estimated glomerular filtration rate (eGFR).
Purpose of the Study:
- To investigate the impact of a 100-km ultramarathon on kidney function.
- To compare changes in creatinine clearance with eGFR and AKI criteria.
Main Methods:
- Twenty healthy male amateur runners participated in a 100-km track run.
- Blood and urine samples were collected pre-run, every 25 km, and 12 hours post-run.
- Creatinine clearance, eGFR (MDRD, CKD-EPI, Cockcroft-Gault), urea, and uric acid were measured.
Main Results:
- Creatinine, urea, and uric acid levels increased post-run (p < 0.05).
- Five runners met AKI network criteria.
- eGFR significantly decreased, but creatinine clearance remained stable.
- No overall decrease in kidney function was observed.
Conclusions:
- Creatinine clearance, a reliable measure of glomerular filtration rate (GFR), remained unchanged.
- Despite transient increases in creatinine and meeting AKI criteria in some individuals, ultramarathon running did not impair overall kidney function.
- Current evidence suggests long-distance running is not detrimental to kidney health.
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