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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies
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Stem-Cell Therapy Advances in China.

Lei Hu1, Bin Zhao1, Songlin Wang1,2

  • 11 Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology , Beijing, China.

Human Gene Therapy
|December 30, 2017
PubMed
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China

Keywords:
Chinabasic researchgene therapytranslational research

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Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Medical Research

Background:

  • Stem-cell therapy offers significant potential for treating diverse diseases and injuries.
  • Chinese government funding has accelerated stem-cell research, leading to increased publication output and quality.
  • Key research areas include cell reprogramming, stem-cell homeostasis, gene modification, and immunomodulation.

Purpose of the Study:

  • To review recent advancements in stem-cell research in China.
  • To discuss the future prospects of stem-cell therapies originating from China.

Main Methods:

  • Analysis of publication trends and quality in stem-cell research over the past five years.
  • Overview of translational studies, including basic and preclinical investigations.
  • Summary of infrastructure development, such as stem-cell banks and clinical trial registrations.

Main Results:

  • Significant growth in the quantity and quality of stem-cell research publications from China.
  • Increased number of translational studies and established stem-cell banks.
  • A robust pipeline with stem-cell drugs in approval and numerous registered clinical trials.

Conclusions:

  • China's stem-cell research is rapidly advancing, driven by government support and infrastructure development.
  • Continued investment and regulatory refinement are expected to foster a boom in stem-cell therapies.
  • The nation is poised for significant contributions to the global field of regenerative medicine.