Related Experiment Video
Updated: Feb 16, 2026
07:04
A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
Published on: October 24, 2017
9.0K
Experience with dasatinib and nilotinib use in pregnancy
Theodora Barkoulas1, Philip D Hall1
1South Carolina College of Pharmacy, Medical University of South Carolina, USA.
Summary
Dasatinib and nilotinib, used for chronic myeloid leukemia (CML), may pose risks during pregnancy. Current data suggests no clear link between dose, exposure, or trimester and adverse outcomes, but caution is advised.
Area of Science:
- Oncology
- Pharmacology
- Reproductive Medicine
Background:
- Chronic myeloid leukemia (CML) treatment during pregnancy poses significant challenges.
- Dasatinib and nilotinib are tyrosine kinase inhibitors (TKIs) used for CML, including resistant cases.
- Animal studies indicate potential teratogenicity and mortality with dasatinib and nilotinib exposure during organogenesis.
Purpose of the Study:
- To review existing human pregnancy data for dasatinib and nilotinib use in CML patients.
- To evaluate the relationship between TKI exposure (dose, duration, trimester) and patient/fetal outcomes.
- To inform clinical practice regarding CML management in pregnant individuals.
Main Methods:
- Systematic review of human pregnancy case reports and studies involving dasatinib or nilotinib.
- Analysis of reported patient demographics, CML characteristics, TKI treatment details, and pregnancy outcomes.
- Assessment of fetal outcomes, including malformations and survival, in relation to maternal TKI exposure.
Main Results:
- Limited human data suggests dasatinib and nilotinib may pose risks to the fetus.
- No definitive correlation was established between TKI dose, duration of exposure, trimester of use, and adverse patient or fetal outcomes.
- Significant fetal harm, including skeletal malformations and mortality, was observed in animal studies.
Conclusions:
- Healthcare providers must counsel women of childbearing potential with CML about the potential risks of dasatinib and nilotinib during pregnancy.
- Current evidence does not allow for definitive conclusions on dose-response or trimester-specific risks in humans.
- Alternative CML management strategies, such as interferon alfa or leukapheresis, alongside TKI discontinuation, may be safer during pregnancy.
Related Concept Videos
01:12What is an Experiment?
19.2K
An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
19.2K
01:19Thomson's e/m Experiment
7.0K
In a beam of charged particles created by a heated cathode, the particles move at different speeds. However, many applications need a beam with uniform particle speeds. An arrangement known as a velocity selector uses electric and magnetic fields to pick particles with a particular speed from the beam.
A particle with charge q, speed v, and mass m enters an area from the top, where the magnetic and electric fields are perpendicular both to the particle's motion and to one another. The magnetic...
A particle with charge q, speed v, and mass m enters an area from the top, where the magnetic and electric fields are perpendicular both to the particle's motion and to one another. The magnetic...
7.0K
01:13Controls in Experiments
18.5K
When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...
18.5K
01:13Randomized Experiments
9.1K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Simple randomization
Simple...
9.1K
01:16Crossover Experiments
4.6K
Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
4.6K
03:20The Stanford Prison Experiment
24.8K
The famous and controversial Stanford Prison Experiment, conducted by social psychologist Philip Zimbardo and his colleagues at Stanford University, demonstrated the power of social roles, social norms, and scripts.
24.8K