Related Experiment Video

Updated: Feb 16, 2026

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
09:38

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

9.2K

Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients

Dennis Plenker1,2, Miriam Bertrand3, Adrianus J de Langen4

  • 1Molecular Pathology, Institute of Pathology, University of Cologne, Cologne, Germany.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|December 30, 2017
PubMed

Insights

Crizotinib shows clinical response in patients with MET rearrangements, including gene fusions. These MET alterations represent actionable targets in lung cancer, confirmed by cellular models.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Structural alterations in the MET receptor tyrosine kinase can drive cancer progression.
  • Identifying actionable targets is crucial for effective lung cancer treatment.

Purpose of the Study:

  • To investigate the clinical efficacy of MET inhibition in patients with structural MET alterations.
  • To functionally characterize these MET alterations in cellular models.

Main Methods:

  • Next-generation sequencing (NGS) for identifying MET alterations.
  • Treatment of patients with crizotinib, a MET and ALK inhibitor.
  • Analysis of cellular models expressing MET kinase alterations.

Main Results:

  • Three patients with structural MET alterations were identified.
  • Two patients had MET gene fusions (KIF5B-MET, STARD3NL-MET).
  • All three patients showed partial response to crizotinib treatment.

Conclusions:

  • Crizotinib demonstrates clinical activity in patients with MET rearrangements.
  • Structural MET alterations are potential therapeutic targets in lung cancer.
  • Functional validation in cellular models supports clinical findings.

More Related Videos

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma13:18

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

1.8K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

8.0K

Related Concept Videos

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
15.2K
Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

4.5K
Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.4K
Alterations in Respiration II01:30

Alterations in Respiration II

There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.9K
Photoreceptors and Plant Responses to Light02:00

Photoreceptors and Plant Responses to Light

Light plays a significant role in regulating the growth and development of plants. In addition to providing energy for photosynthesis, light provides other important cues to regulate a range of developmental and physiological responses in plants.
28.6K
Altered States of Awareness01:06

Altered States of Awareness

Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.2K