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Kasabach-Merritt syndrome combined with hypercalcemia: A case report

Runying Zou1, Fang Peng1, Tian Yu1

  • 1Department of Hematology and Oncology of Children's Medical Center, Hunan Provincial People's Hospital, Changsha, Hunan 410005, P.R. China.

Experimental and Therapeutic Medicine
|December 30, 2017
PubMed

Insights

This case report details the rare co-occurrence of Kasabach-Merritt syndrome (KMS) and hypercalcemia (HC) in an infant. Surgical removal of the hemangioma proved the most effective treatment, normalizing blood calcium levels.

Area of Science:

  • Pediatric Hematology
  • Pediatric Oncology
  • Clinical Case Reports

Background:

  • Kasabach-Merritt syndrome (KMS) is a rare condition characterized by a vascular tumor and coagulopathy.
  • Hypercalcemia (HC) is an uncommon but serious complication associated with KMS.
  • This report addresses the diagnostic and therapeutic challenges of KMS coexisting with HC in an infant.

Purpose of the Study:

  • To present a case of an infant diagnosed with Kasabach-Merritt syndrome (KMS) and hypercalcemia (HC).
  • To describe the diagnostic process and treatment course for this rare combined condition.
  • To highlight the efficacy of surgical intervention for KMS with HC.

Main Methods:

  • A 35-day-old infant with upper arm swelling and thrombocytopenia was treated with medications including gamma-globulin, heparin, platelet transfusions, cryoprecipitate, fibrinogen, and propranolol.
  • The infant was subsequently hospitalized for surgical resection of the hemangioma via pipeline arteriosclerosis embolization.
  • Treatment efficacy was monitored through clinical symptoms and blood calcium levels.

Main Results:

  • Initial medical management for KMS and HC included anticoagulation, transfusions, and propranolol.
  • Surgical resection of the hemangioma was performed at two months post-admission.
  • Post-surgery, the infant's blood calcium levels normalized, indicating successful management of hypercalcemia.

Conclusions:

  • Kasabach-Merritt syndrome (KMS) combined with hypercalcemia (HC) is an exceptionally rare clinical presentation.
  • Multidisciplinary medical management is crucial for stabilizing patients with KMS and HC.
  • Surgical resection of the hemangioma is the most effective treatment strategy for resolving both KMS and associated hypercalcemia.

Keywords:
Kasabach-Merritt syndromehemangiomahypercalcemiathrombocytopenia

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