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Crosstalk between the Notch signaling pathway and non-coding RNAs in gastrointestinal cancers

Yangyang Pan1, Yuyan Mao2, Rong Jin1

  • 1Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

Oncology Letters
|December 30, 2017
PubMed

Insights

The Notch signaling pathway regulates cell processes and tumor progression. This review explores how Notch signaling interacts with non-coding RNAs (microRNAs, long non-coding RNAs, circular RNAs) to influence gastrointestinal cancer cell fate.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The Notch signaling pathway is crucial for cell-to-cell communication and development.
  • It plays a significant role in regulating cell proliferation, apoptosis, migration, invasion, angiogenesis, and metastasis.
  • Notch signaling is implicated in the progression of various cancers, including gastrointestinal cancers.

Purpose of the Study:

  • To review the current understanding of Notch-mediated processes in gastrointestinal cancer cells.
  • To elucidate the crosstalk between Notch signaling and non-coding RNAs in gastrointestinal cancer.
  • To summarize the impact of this crosstalk on gastrointestinal cancer cell fate.

Main Methods:

  • Literature review of existing studies on Notch signaling and non-coding RNAs in cancer.
  • Analysis of research focusing on the interplay between Notch pathway components and non-coding RNAs (miRNAs, lncRNAs, circRNAs).
  • Synthesis of findings related to gastrointestinal cancer cell behavior and progression.

Main Results:

  • Notch signaling directly influences key cellular processes vital for cancer development and spread.
  • Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, are significantly involved in tumor progression.
  • Evidence indicates a complex crosstalk between Notch signaling and these non-coding RNAs, affecting gastrointestinal cancer cell outcomes.

Conclusions:

  • The interaction between Notch signaling and non-coding RNAs is a critical determinant of gastrointestinal cancer progression.
  • Understanding this crosstalk offers potential therapeutic targets for gastrointestinal cancers.
  • Further research into the specific mechanisms of Notch-non-coding RNA interactions is warranted for novel treatment strategies.
Keywords:
Notchcircular RNAsgastrointestinal cancerlong non-coding RNAsmicroRNAs

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