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Modeling Chemotherapy Resistant Leukemia In Vitro
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Function of insulin-like growth factor 1 receptor in cancer resistance to chemotherapy

Jingsheng Yuan1, Zhijie Yin1, Kaixiong Tao1

  • 1Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.

Oncology Letters
|December 30, 2017
PubMed

Insights

Drug resistance in cancer chemotherapy is complex. This study details how the Insulin-like Growth Factor 1 Receptor (IGF1R) promotes chemoresistance by affecting cell growth, apoptosis, and drug transporters.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Drug resistance is a major challenge in cancer chemotherapy, leading to treatment failure.
  • Understanding resistance mechanisms is crucial for developing more effective cancer therapies.
  • The Insulin-like Growth Factor 1 Receptor (IGF1R) is implicated in tumor progression, but its role in chemoresistance is not fully understood.

Purpose of the Study:

  • To elucidate the role of IGF1R in the development of chemotherapeutic resistance in cancer.
  • To detail the molecular mechanisms by which IGF1R contributes to chemoresistance.

Main Methods:

  • Review and synthesis of existing research on IGF1R signaling pathways.
  • Analysis of IGF1R's involvement in key cellular processes related to chemoresistance.

Main Results:

  • IGF1R promotes chemoresistance by enhancing tumor cell proliferation.
  • IGF1R inhibits apoptosis, contributing to treatment failure.
  • IGF1R influences the expression of ATP-binding cassette transporter proteins.
  • IGF1R interacts with the extracellular matrix, impacting drug resistance.

Conclusions:

  • IGF1R plays a significant role in mediating tumor chemoresistance through multiple mechanisms.
  • Targeting IGF1R and its downstream pathways may offer novel therapeutic strategies for overcoming chemotherapy resistance.
Keywords:
cancerchemotherapeutic resistanceinsulin-like growth factor 1 receptormechanismsreview

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