Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Septo-optic dysplasia: MR imaging.

A J Barkovich1, E K Fram, D Norman

  • 1Department of Radiology, Letterman Army Medical Center, Presidio of San Francisco, CA 94129.

Radiology
|April 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dandy-Walker Phenotype with Brainstem Involvement: 2 Distinct Subgroups with Different Prognosis.

AJNR. American journal of neuroradiology·2023
Same author

Refining the Neuroimaging Definition of the Dandy-Walker Phenotype.

AJNR. American journal of neuroradiology·2022
Same author

Thalamus L-Sign: A Potential Biomarker of Neonatal Partial, Prolonged Hypoxic-Ischemic Brain Injury or Hypoglycemic Encephalopathy?

AJNR. American journal of neuroradiology·2022
Same author

Aberrant Structural Brain Connectivity in Adolescents with Attentional Problems Who Were Born Prematurely.

AJNR. American journal of neuroradiology·2018
Same author

Expanding the Distinctive Neuroimaging Phenotype of <i>ACTA2</i> Mutations.

AJNR. American journal of neuroradiology·2018
Same author

Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study.

AJNR. American journal of neuroradiology·2017

Septo-optic dysplasia involves optic nerve hypoplasia and septum pellucidum abnormalities. Research suggests this condition comprises two distinct patient subsets with differing developmental origins and brain abnormalities.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Radiology

Background:

  • Septo-optic dysplasia (SOD) is characterized by optic nerve hypoplasia and midline brain abnormalities.
  • The condition presents with diverse clinical and pathological manifestations, complicating classification.
  • Associated conditions include hypothalamic-pituitary dysfunction and schizencephaly.

Purpose of the Study:

  • To investigate the heterogeneity of septo-optic dysplasia.
  • To identify distinct patient subsets within the septo-optic dysplasia diagnosis.
  • To correlate imaging findings with potential differences in embryogenesis and neuropathology.

Main Methods:

  • Retrospective review of magnetic resonance images (MRIs) from 11 patients.
  • Clinical and radiographic evidence of septo-optic dysplasia was assessed.

Related Experiment Videos

  • Analysis focused on identifying patterns and variations in brain abnormalities.

    • Main Results:

    • The study identified two distinct subsets of patients within the septo-optic dysplasia diagnosis.
    • These subsets exhibited differences in embryogenesis and neuropathologic findings.
    • The identified subsets help explain the wide range of clinical and radiologic presentations.

    Conclusions:

    • Septo-optic dysplasia is not a single entity but likely represents at least two distinct conditions.
    • Understanding these subsets is crucial for accurate diagnosis and understanding the diverse manifestations of SOD.
    • Further research into the embryogenesis of these subsets is warranted.