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Updated: Feb 16, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.9K
Predicting castration-resistant prostate cancer after combined androgen blockade
Miao He1, Haina Liu1, Jingyi Cao2
1Department of Nuclear Medicine, Xuzhou Cancer Hospital, Jiangsu Province, Xuzhou, China.
Oncotarget
|December 30, 2017
Summary
Early-stage castration resistance in prostate cancer (CRPC) with bone metastasis is predicted by longer times to reach the lowest prostate-specific antigen (PSA) value. Bone scans effectively diagnose and grade bone metastases in these patients.
Area of Science:
- Oncology
- Nuclear Medicine
- Urology
Background:
- Prostate cancer (PC) frequently metastasizes to bone.
- Castration resistance (CRPC) is a critical progression in advanced PC.
- Early identification of factors predicting CRPC is essential for treatment optimization.
Purpose of the Study:
- To analyze 99Tcm-MDP bone scans in patients with bone metastatic PC.
- To identify factors influencing early-stage castration resistance in PC patients with bone metastasis.
Main Methods:
- Retrospective analysis of clinical data from 92 patients with bone metastatic PC treated with maximal androgen blockade.
- 99Tcm-MDP bone scans for metastasis detection and grading.
- Regular monitoring of prostate-specific antigen (PSA) levels.
Main Results:
- A total of 464 bone metastases were detected initially, with 30.6% in the pelvis.
- Median time to CRPC occurrence was 23 months after treatment.
- Longer time to reach the lowest PSA value independently predicted early-onset CRPC (<1 year).
- Gleason score >8, higher post-treatment PSA, and shorter time to lowest PSA predicted poorer treatment response.
Conclusions:
- 99Tcm-MDP bone scans are valuable for diagnosing and grading prostate cancer bone metastasis.
- Predictive factors for early CRPC and poorer treatment response were identified.
- These findings aid in managing advanced prostate cancer with bone metastasis.
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