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Updated: Feb 16, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Potential role of NDRG2 in reprogramming cancer metabolism and epithelial-to-mesenchymal transition
Xiang-Liu Chen1, Lan Lei1, Lian-Lian Hong1
1Zhejiang Cancer Institute, Zhejiang Cancer Hospital, Zhejiang Cancer Center, Gongshu District, Hangzhou, P.R. China.
Abstract:
Epithelial-to-mesenchymal transition (EMT) allows a cell with epithelial characteristics to transdifferentiate into a cell with mesenchymal characteristics, which is recognized as a key priming event for the initiation and evolvement of cancer metastasis. Accumulating data have shown that aberrant cancer metabolism contributes to the execution of EMT and cancer metastasis through multiple pathological pathways. Recently, the N-MYC downstream-regulated gene 2 (NDRG2), as a tumor suppressor and metabolism-related gene in various cancers, has been widely noted. NDGR2 is associated with energy metabolism, especially glycose metabolism. Hence, we propose a hypothesis that EMT is repressed by NDRG2 via cancer metabolic reprogramming, and summarize the pathological processes and molecular pathways related to the regulation of NDRG2.
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