Related Experiment Video
Updated: Aug 7, 2026
12:04
Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
Published on: January 6, 2011
Subthalamic deep brain stimulation and trunk posture in Parkinson's disease
C A Artusi1, M Zibetti1, A Romagnolo1
1Department of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy.
Acta Neurologica Scandinavica
|December 30, 2017
Summary
Subthalamic nucleus deep brain stimulation (STN-DBS) significantly improved trunk posture abnormalities in Parkinson's disease (PD) patients. STN-DBS alone showed a 41.4% improvement, offering potential for advanced PD posture management.
Area of Science:
- Neurology
- Neurosurgery
- Movement Disorders
Background:
- Parkinson's disease (PD) frequently causes trunk posture abnormalities.
- Subthalamic nucleus deep brain stimulation (STN-DBS) is a treatment for advanced PD.
- Trunk posture issues can significantly impact quality of life in PD patients.
Purpose of the Study:
- To evaluate the effectiveness of STN-DBS for correcting trunk posture abnormalities in Parkinson's disease patients.
- To analyze the impact of STN-DBS on specific postural conditions like camptocormia and Pisa syndrome.
Main Methods:
- Retrospective analysis of 101 PD patients with trunk abnormalities treated with STN-DBS.
- Trunk posture was assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) grading.
- Compared pre-surgery (Medication-Off) to post-surgery (Stimulation-On/Medication-Off) for STN-DBS's independent effect.
- Evaluated combined STN-DBS and levodopa effects by comparing Medication-On (pre-surgery) to Stimulation-On/Medication-On (post-surgery).
Main Results:
- STN-DBS alone improved trunk posture severity by 41.4% (P < .001), with 78.2% of patients showing at least a 1-point improvement.
- The combined effect of STN-DBS and levodopa yielded a 30.9% improvement (P = .061).
- In patients with camptocormia and Pisa syndrome, STN-DBS independently improved posture by 42.7% (P < .001).
Conclusions:
- STN-DBS demonstrates significant potential in ameliorating trunk posture abnormalities in advanced Parkinson's disease.
- The independent effect of STN-DBS on posture is notable, even in complex cases like camptocormia and Pisa syndrome.
- Further research may explore optimizing STN-DBS for postural management in PD.
Related Concept Videos
01:15Parkinson's Disease: Overview
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
01:24Parkinson's Disease: Treatment
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
01:11Alterations in Muscle Tone lll
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...