Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcription Factors02:16

Transcription Factors

82.9K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.9K
Factors Affecting Solubility04:01

Factors Affecting Solubility

37.4K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
37.4K
Transcription Elongation Factors02:35

Transcription Elongation Factors

14.1K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
14.1K
Factors Affecting Drug Distribution: Miscellaneous Factors01:19

Factors Affecting Drug Distribution: Miscellaneous Factors

1.0K
Drug distribution in the human body is a complex process influenced by various individual factors, including age, pregnancy, obesity, diet, body water composition, pH levels, and specific disease conditions.
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
1.0K
Electrolytes: van't Hoff Factor03:08

Electrolytes: van't Hoff Factor

37.2K
Colligative Properties of Electrolytes
The colligative properties of a solution depend only on the number, not on the identity, of solute species dissolved. The concentration terms in the equations for various colligative properties (freezing point depression, boiling point elevation, osmotic pressure) pertain to all solute species present in the solution. Nonelectrolytes dissolve physically without dissociation or any other accompanying process. Each molecule that dissolves yields one...
37.2K
Factors Affecting Protein-Drug Binding: Drug-Related Factors01:18

Factors Affecting Protein-Drug Binding: Drug-Related Factors

508
Drug binding to proteins is a complex phenomenon influenced by various drug-related factors, each playing a significant role in the interaction between drugs and proteins within the body.
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...
508

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural history and outcomes of post-operative atrial fibrillation after non-cardiac surgery: a clinically adjudicated single-center retrospective study.

Clinical research in cardiology : official journal of the German Cardiac Society·2026
Same author

Outcomes of Early Sodium-Glucose Cotransporter Two Inhibitor Use in Takotsubo Syndrome: Insights From a Multicenter Real-World Cohort Study.

The American journal of cardiology·2026
Same author

Glucagon-Like Peptide-1 Receptor Agonists and Cardiovascular Outcomes in Patients With Atherosclerotic Cardiovascular Disease and Obesity Without Diabetes.

The American journal of cardiology·2026
Same author

Racial and Ethnic Disparities in Inpatient Outcomes of Tricuspid Transcatheter Edge-to-Edge Repair in the United States.

Journal of the Society for Cardiovascular Angiography & Interventions·2026
Same author

Electrical cardioversion in patients with left ventricular thrombus: A systematic review of safety and thromboembolic risk.

JRSM cardiovascular disease·2026
Same author

A New Prognostic Score for Predicting Atrial Fibrillation Recurrence After Electrical Cardioversion: SLASH Score.

Pacing and clinical electrophysiology : PACE·2026

Related Experiment Video

Updated: Feb 16, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
08:30

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

11.8K

Von Willebrand factor revisited.

Senan J Yasar1, Obai Abdullah1, William Fay1

  • 1University of Missouri, Columbia, MissouriMissouri.

Journal of Interventional Cardiology
|December 30, 2017
PubMed
Summary

New biomarkers like von Willebrand factor activity can help assess transcatheter aortic valve replacement (TAVR) complications, supplementing traditional imaging methods for aortic stenosis patients.

Keywords:
TAVITAVRVon Willebrand factoraortic stenosis

More Related Videos

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.9K
Measuring Changes in Tactile Sensitivity in the Hind Paw of Mice Using an Electronic von Frey Apparatus
07:49

Measuring Changes in Tactile Sensitivity in the Hind Paw of Mice Using an Electronic von Frey Apparatus

Published on: December 19, 2013

35.4K

Related Experiment Videos

Last Updated: Feb 16, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
08:30

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

11.8K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.9K
Measuring Changes in Tactile Sensitivity in the Hind Paw of Mice Using an Electronic von Frey Apparatus
07:49

Measuring Changes in Tactile Sensitivity in the Hind Paw of Mice Using an Electronic von Frey Apparatus

Published on: December 19, 2013

35.4K

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Interventional Cardiology

Background:

  • Degenerative aortic valve stenosis is a prevalent valvular heart disease in developed nations.
  • Transcatheter aortic valve replacement (TAVR) has advanced treatment, prompting research into improved techniques and reduced mortality.
  • Current assessment of TAVR relies heavily on imaging like transesophageal echocardiography and aortic root angiography.

Purpose of the Study:

  • To explore novel biomarkers for managing patients with aortic stenosis.
  • To evaluate the potential of von Willebrand factor (vWF) activity and high molecular weight multimer (vWF-HMW) levels as biomarkers in TAVR.
  • To assess if vWF markers can supplement or improve upon existing imaging modalities for TAVR complication assessment.

Main Methods:

  • Investigated the utility of von Willebrand factor activity and high molecular weight multimer levels.
  • Focused on the potential for intraoperative, point-of-care assessment.
  • Compared biomarker assessment with established imaging techniques for TAVR.

Main Results:

  • von Willebrand factor activity and vWF-HMW levels show promise as effective biomarkers.
  • These biomarkers offer potential for point-of-care, intraoperative assessment.
  • Biomarker assessment may supplement current imaging modalities for evaluating TAVR.

Conclusions:

  • von Willebrand factor assessment represents a significant advancement in TAVR management.
  • These biomarkers could provide a more accurate evaluation of TAVR complications.
  • Further research is warranted to fully integrate vWF markers into clinical practice for aortic stenosis patients undergoing TAVR.