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Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
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Melasma, a photoaging disorder.

Thierry Passeron1,2, Mauro Picardo3

  • 1Department of Dermatology, Université Côte D'Azur, Centre Hospitalier Universitaire Nice, Nice, France.

Pigment Cell & Melanoma Research
|December 30, 2017
PubMed
Summary
This summary is machine-generated.

Melasma, a common skin pigment disorder, is challenging to treat. New research suggests melasma may be a photoaging skin condition in genetically susceptible individuals, impacting treatment and prevention strategies.

Keywords:
UVangiogenesiselastosismelasmaphotoaging skinsebocytesvisible light

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Area of Science:

  • Dermatology
  • Skin Biology
  • Hyperpigmentation Disorders

Background:

  • Melasma is a prevalent hyperpigmentary disorder significantly impacting quality of life.
  • Current treatments for melasma are often challenging and yield suboptimal results.
  • While genetics and hormones are known factors, recent research uncovers additional contributors to melasma pathophysiology.

Purpose of the Study:

  • To summarize the latest scientific evidence on the pathophysiology of melasma.
  • To propose a novel perspective on melasma as a photoaging skin disorder.
  • To inform clinical practice regarding melasma treatment and prevention.

Main Methods:

  • Literature review of recent studies on melasma pathophysiology.
  • Synthesis of evidence implicating various molecular and cellular pathways.
  • Analysis of the role of environmental factors, particularly photoexposure.

Main Results:

  • The pathophysiology of melasma involves more factors than previously understood, including genetic predisposition and hormonal influences.
  • Emerging evidence points to photoaging mechanisms playing a significant role in melasma development.
  • Melasma may be conceptualized as a photoaging skin disorder in genetically susceptible individuals.

Conclusions:

  • Melasma's complex pathophysiology involves genetic, hormonal, and photoaging components.
  • Viewing melasma as a photoaging disorder offers new therapeutic and preventive avenues.
  • Clinicians should consider these updated insights for improved patient management of melasma.