The Correlates of Kidney Dysfunction – Tumour Nephrectomy Database (CKD-TUNED) Study: Protocol for a Prospective...

Area of Science:

• Nephrology
• Oncology
• Urology

Background:

• Tumor nephrectomy poses a significant risk of adverse renal functional outcomes.
• Limited strategies exist for predicting patients at increased risk of these outcomes.

Purpose of the Study:

• To evaluate the risk of chronic kidney disease and end-stage kidney disease in tumor nephrectomy patients.
• To establish a prospective observational study for assessing renal functional outcomes.
• To create a resource for future investigations into kidney dysfunction post-nephrectomy.

Main Methods:

• Prospective observational study design.
• Analysis of clinical data.
• Collection of tissue, urine, and blood samples for a tissue repository.
• Ongoing recruitment with a projected sample size of 700-1000 subjects.

Main Results:

• Ethics and site-specific approvals obtained.
• Infrastructure in place for study execution.
• Study methods undergoing validation and refinement.
• 267 participants enrolled as of June 2017.

Conclusions:

• The study anticipates identifying risk factors for adverse renal functional outcomes.
• Potential for developing predictive models with clinical utility.
• Expected to improve patient outcomes following tumor nephrectomy.