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Updated: Feb 16, 2026

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease
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Amyloid Biomarkers in Conformational Diseases at Face Value: A Systematic Review

Maria Fernanda Avila-Vazquez1,2, Nelly F Altamirano-Bustamante3, Myriam M Altamirano-Bustamante4

  • 1Unidad de Investigación en Enfermedades Metabólicas, Centro Médico Nacional Siglo XXI, IMSS, Mexico City 06720, Mexico. feravilaibero@gmail.com.

Molecules (Basel, Switzerland)
|December 30, 2017
PubMed

Insights

Early biomarkers for conformational diseases are crucial in proteomic medicine. This review explores their diagnostic and therapeutic roles, highlighting immunoassays and chaperone-based treatments.

Area of Science:

  • Proteomic medicine
  • Translational medicine
  • Biomarker discovery

Background:

  • Conformational diseases are a growing area in proteomic medicine.
  • Early biomarkers for target cell failure are challenging but vital for translational medicine.
  • These biomarkers possess a multidimensional role as diagnostic indicators and therapeutic targets.

Purpose of the Study:

  • To systematically review the multidimensionality of early biomarkers in conformational diseases.
  • To analyze the strengths and limitations of current diagnostic and therapeutic approaches.
  • To explore future possibilities in this evolving field.

Main Methods:

  • Systematic review following PICO and Prisma methodologies.
  • Analysis of nuclear diagnostic methods including immunoassays (ELISA, immunodot, western blot).
  • Evaluation of therapeutic strategies focusing on pharmacochaperones and molecular chaperones.

Main Results:

  • Early biomarkers play a dual role in diagnosis and therapy for conformational diseases.
  • Immunoassays are key nuclear diagnostic tools.
  • Pharmacochaperones and molecular chaperones represent promising therapeutic avenues.

Conclusions:

  • Conformational diseases require evolving diagnostic and therapeutic paradigms.
  • The multidimensionality of biomarkers offers significant potential for personalized medicine.
  • Future research should focus on refining diagnostic accuracy and therapeutic efficacy of chaperones.
Keywords:
Alzheimer’s diseaseamyloid oligomersbiomarkerconformational diseasescytotoxic oligomersdiabetes mellitus

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