[Advantages of single-dose treatment of vaginal Candida albicans infection]

One-hundred forty women (60 pregnant and 80 non-pregnant women) with a history of Candida albicans infection were examined one month before treatment and were reexamined one month after treatment. Administration of a single agent consisting of 2,300 mg tablets of GynoTragoven (isoconazole nitrate, Schering, AG) resulted in immediate clinical improvement. One month after treatment, the success rate was 85-100 p. cent for non-pregnant women, and 83-100 p. cent for pregnant women. No side-effects were observed following therapy. According to studies published, a high percentage of infections develop during pregnancy, especially during the second (35 p. cent) and third (31.5 p. cent) trimesters. Because of the high rate of infections during pregnancy, preventive therapy should be considered during the final weeks of pregnancy, to prevent intrauterine infection during parturition.