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Related Experiment Video

Updated: Feb 16, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

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Published on: October 17, 2025

CD9 expression indicates a poor outcome in acute lymphoblastic leukemia.

Peiqi Liang, Miao Miao, Zhuogang Liu

Cancer Biomarkers : Section a of Disease Markers

|December 30, 2017

Summary

CD9 expression is linked to specific acute lymphoblastic leukemia (ALL) subtypes and clinical features. CD9-positive ALL patients show a poorer prognosis, highlighting CD9 as a potential prognostic marker.

Keywords:

Acute lymphoblastic leukemia CD9 clinical characteristics prognosis

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Area of Science:

Hematology
Oncology
Immunology

Background:

Acute lymphoblastic leukemia (ALL) is a heterogeneous hematologic malignancy.
Understanding molecular markers like CD9 can refine prognostic assessments in ALL.

Purpose of the Study:

To investigate the association between CD9 expression and clinical characteristics of acute lymphoblastic leukemia (ALL).
To evaluate the prognostic significance of CD9 in ALL patients.

Main Methods:

Retrospective analysis of 112 newly diagnosed ALL patients.
Flow cytometry utilized for CD9 expression detection.
Clinical data and survival outcomes were collected and analyzed.

Main Results:

CD9 expression was more prevalent in B-cell ALL and older patients (>40 years).
CD9 positivity correlated with higher BCR-ABL fusion gene rates and elevated neutrophil counts (P=0.004).
CD9 expression did not influence response to induction chemotherapy but was associated with a lower 2-year overall survival rate.

Conclusions:

CD9 expression serves as a predictive marker for specific clinical features in ALL.
CD9 positivity indicates a less favorable prognosis in acute lymphoblastic leukemia patients.