Related Experiment Video

Updated: Feb 16, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

292

The Effect of Midface Advancement Surgery on Obstructive Sleep Apnoea in Syndromic Craniosynostosis

Clair Saxby1, Kate A Stephenson1, Katherine Steele1

  • 1Ear, Nose and Throat Surgery.

The Journal of Craniofacial Surgery
|December 30, 2017
PubMed

Insights

Midface advancement surgery in children with syndromic craniosynostosis improved obstructive sleep apnoea (OSA) severity, with most patients showing better Apnoea-Hypopnoea Index scores and OSA grading post-surgery.

Area of Science:

  • Pediatric surgery
  • Sleep medicine
  • Craniofacial anomalies

Background:

  • Children with syndromic craniosynostosis often experience obstructive sleep apnoea (OSA).
  • Midface hypoplasia is a common feature in syndromic craniosynostosis, potentially contributing to airway obstruction.

Purpose of the Study:

  • To evaluate the impact of midface advancement surgery on the severity of obstructive sleep apnoea (OSA) in children with syndromic craniosynostosis.
  • To analyze changes in sleep study parameters before and after surgical intervention.

Main Methods:

  • Retrospective analysis of pre- and postoperative sleep study data from 65 children.
  • Comparison of sleep study parameters including Apnoea-Hypopnoea Index (AHI) and oxygen saturation.
  • Patients underwent either monobloc or bipartition midface advancement surgery.

Main Results:

  • A higher proportion of patients achieved normal OSA grading post-surgery (42.3%) compared to pre-surgery (23.1%).
  • 71% of patients demonstrated a decrease in their Apnoea-Hypopnoea Index (AHI) after surgery.
  • No significant changes were observed in oxygen desaturation index or oxygen saturation nadir.

Conclusions:

  • Midface advancement surgery shows a positive trend in improving OSA severity in children with syndromic craniosynostosis.
  • Improvements in AHI and OSA grading were noted, but oxygenation parameters did not consistently change.
  • This study represents one of the largest reviews on the effects of midface advancement on sleep parameters in this patient population.
Abstract

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