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Breast cancer: Lesser-known facets and hypotheses
1Bioinformatics and Medical Informatics Research Center, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182, USA.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 30, 2017
Summary
Breast cancer prevention through lifestyle changes is crucial. Understanding its inflammatory endocrinopathy nature, driven by estrogenic compounds and acidosis, offers a sustainable solution beyond traditional therapies.
Area of Science:
- Oncology and Endocrinology: Investigating the intricate links between environmental factors, lifestyle, and breast cancer development.
Background:
- Breast cancer is the most prevalent cancer in women, with increasing incidence linked to environmental degradation and lifestyle choices.
- Current treatments for breast cancer have limitations, including side effects, relapse rates, and high mortality, necessitating alternative approaches.
- A lifestyle influenced by estrogenic compounds, endocrine disruption, and acidosis elevates aromatase levels, promoting harmful estrogenic forms and epithelial proliferation.
Purpose of the Study:
- To provide a comprehensive review of breast cancer as an inflammatory endocrinopathy.
- To highlight the role of lifestyle modifications and awareness in breast cancer prevention and management.
Main Methods:
- Literature review synthesizing current research on breast cancer etiology, hormonal influences, and environmental impact.
- Analysis of the mechanisms linking lifestyle factors to endocrine disruption and cancer progression.
Main Results:
- Identified lifestyle factors, including exposure to estrogenic compounds and metabolic disturbances like acidosis, as key drivers of breast cancer.
- Established a connection between elevated aromatase activity and the promotion of aggressive estrogenic forms contributing to cancer.
Conclusions:
- Breast cancer can be viewed as an inflammatory endocrinopathy, suggesting a paradigm shift in understanding and treatment.
- Prevention through lifestyle discipline and increased awareness is presented as a more sustainable and effective long-term strategy than solely relying on therapeutic interventions.
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