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Updated: Feb 16, 2026

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
Correlation of dissolution and disintegration results for an immediate-release tablet
Beverly Nickerson1, Angela Kong2, Paul Gerst1
1Pfizer Worldwide Research and Development, Analytical Research and Development, 558 Eastern Point Road, Groton, CT 06340, United States.
Abstract:
The drug release rate of a rapidly dissolving immediate-release tablet formulation with a highly soluble drug is proposed to be controlled by the disintegration rate of the tablet. Disintegration and dissolution test methods used to evaluate the tablets were shown to discriminate manufacturing process differences and compositionally variant tablets. In addition, a correlation was established between disintegration and dissolution. In accordance with ICH Q6A, this work demonstrates that disintegration in lieu of dissolution is suitable as the drug product quality control method for evaluating this drug product.
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