Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fat and pancreatic secretion.

O Olsen1, O B Schaffalitzky de Muckadell, P Cantor

  • 1Dept. of Surgical Gastroenterology C, Rigshospitalet, Copenhagen, Denmark.

Scandinavian Journal of Gastroenterology
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland-Does Variation Matter?

Pediatric blood & cancer·2026
Same author

Activation of RAAS in a rat model of liver cirrhosis: no effect of losartan on renal sodium excretion.

BMC nephrology·2018
Same author

MR scanning, tattoo inks, and risk of thermal burn: An experimental study of iron oxide and organic pigments: Effect on temperature and magnetic behavior referenced to chemical analysis.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2017
Same author

The continuous reaction time test for minimal hepatic encephalopathy validated by a randomized controlled multi-modal intervention-A pilot study.

PloS one·2017
Same author

The use of selective serotonin receptor inhibitors (SSRIs) is not associated with increased risk of endoscopy-refractory bleeding, rebleeding or mortality in peptic ulcer bleeding.

Alimentary pharmacology & therapeutics·2017
Same author

Effects of common chronic medical conditions on psychometric tests used to diagnose minimal hepatic encephalopathy.

Metabolic brain disease·2015
Same journal

Assessing trial eligibility and real-world response to vedolizumab and ustekinumab in patients with ulcerative colitis.

Scandinavian journal of gastroenterology·2026
Same journal

M2 macrophage activation in recurrent acute pancreatitis: an explorative analysis of a randomized controlled trial.

Scandinavian journal of gastroenterology·2026
Same journal

Safety and performance of small bowel capsule endoscopy in patients with surgically altered gastrointestinal anatomy.

Scandinavian journal of gastroenterology·2026
Same journal

Textbook outcome after esophagectomy in Norway - a national cohort study of low- to medium-volume centers.

Scandinavian journal of gastroenterology·2026
Same journal

Fecal calprotectin concentration in adults with and without <i>Helicobacter pylori</i> infection.

Scandinavian journal of gastroenterology·2026
Same journal

Endoloop-clip closure versus hemoclips for large sigmoid colon perforations: a randomized controlled <i>ex vivo</i> study.

Scandinavian journal of gastroenterology·2026
See all related articles

Fat digestion in healthy volunteers stimulates secretin and cholecystokinin (CCK) release. Hormone release depends on fat dose and emulsification, with CCK having a lower release threshold than secretin.

Area of Science:

  • Gastroenterology
  • Endocrinology
  • Human Physiology

Background:

  • Fatty acids in the duodenum stimulate pancreaticobiliary secretion.
  • Secretin and cholecystokinin (CCK) are key hormones regulating digestion.
  • Understanding their release mechanisms is crucial for digestive health.

Purpose of the Study:

  • To investigate the effects of intraduodenal oleic acid on pancreaticobiliary secretion.
  • To examine the impact of varying oleic acid concentrations and emulsification on hormone release.
  • To determine the relationship between fat load, emulsification, and secretin/CCK plasma levels.

Main Methods:

  • 10 healthy volunteers participated in the study.
  • Intraduodenal oleic acid was administered at varying concentrations (0-40 mM).

Related Experiment Videos

  • Different degrees of fat emulsification were tested to assess their impact.

    • Main Results:

    • Secretin and CCK release correlated directly with fat dose and emulsification.
    • CCK release threshold was lower than secretin release threshold.
    • Increased emulsification did not yield a simple correlation between hormone levels and pancreatic secretion.

    Conclusions:

    • Secretin and CCK are released dose-dependently by oleic acid emulsions in humans.
    • Distinct release thresholds exist for secretin and CCK.
    • Fat emulsification influences hormone release, but its precise relationship with pancreatic secretion requires further study.