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The role of DNA methylation in coronary artery disease

Lian Duan1, Junyuan Hu1, Xingjiang Xiong2

  • 1Department of Cardiology, Guang' An men Hospital, China Academy of Chinese Medical Science, No.5 Bei xiange, Xicheng District, Beijing, China; Graduate School, Beijing University of Traditional Chinese Medicine, No.11 North Third Ring Road, Chaoyang District, Beijing, China.

Gene
|December 31, 2017
PubMed

Insights

DNA methylation is linked to coronary artery disease (CAD). This review explores how DNA methylation changes in critical genes, including homocysteine, Alu, and LINE-1, contribute to CAD development and cellular mechanisms.

Area of Science:

  • Epigenetics and Molecular Biology
  • Cardiovascular Disease Research

Background:

  • DNA methylation is an epigenetic mechanism implicated in coronary artery disease (CAD).
  • The precise cellular mechanisms by which critical genes interact to cause CAD remain unclear.
  • Previous research has established links between DNA methylation and CAD development over the past two decades.

Purpose of the Study:

  • To provide an overview of DNA methylation biology, mechanisms, and its role in CAD.
  • To discuss recent findings on DNA methylation in homocysteine, Alu, and LINE-1 elements in CAD.
  • To explore the in vitro and in vivo evidence of DNA methylation's impact on CAD-related genes.

Main Methods:

  • Literature review and synthesis of existing research on DNA methylation and CAD.
  • Analysis of studies investigating DNA methylation changes in specific genes and repetitive elements (homocysteine, Alu, LINE-1).
  • Examination of in vitro and in vivo experimental findings related to DNA methylation in CAD.

Main Results:

  • Significant alterations in DNA methylation of critical genes, including homocysteine, Alu, and LINE-1, are observed in CAD.
  • Evidence from in vitro and in vivo studies supports the role of DNA methylation in CAD pathogenesis.
  • DNA methylation patterns are associated with genomic coding and disease phenotype in CAD.

Conclusions:

  • DNA methylation is a key epigenetic factor in the development of coronary artery disease.
  • Further research into the specific roles of DNA methylation in homocysteine, Alu, and LINE-1 is warranted.
  • Understanding DNA methylation mechanisms offers potential therapeutic perspectives for CAD management.
Keywords:
AluCADDNA methylationHomocysteineLINE-1

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