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Autoimmune arthritis in Ménière's disease: A systematic review of the literature
Lisa Caulley1, Alexandra Quimby1, Jacob Karsh2
1Department of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ottawa, Ontario, Canada; The Ottawa Hospital, Ottawa, Ontario, Canada.
Introduction:
Successful management of patients with Ménière's disease (MD) involves understanding the pathophysiology of the disease and its comorbidities. The role of autoimmune diseases (AD) in MD remains unclear. The aim of this study was to further investigate the association between MD and AD. Specific goals were to characterize the prevalence, distribution, clinical and laboratory findings, and outcomes of autoimmune arthritis (AA) in MD.
Evidence Review:
This systematic review was conducted according to PRISMA guidelines. Articles were identified through searches of MEDLINE, and EMBASE, as well as manual reviews of references, from 1947 to May 2017. We performed a systematic review of randomized-controlled trials (RCTs) and non-RCTs of cases of AA in MD. Due to the heterogeneity of the study methods and measures, a meta-analysis was not possible and a qualitative synthesis of the literature results was performed. The study protocol was registered with PROSPERO database (Trial Registration: CRD42017070516).
Findings:
A total of 237 abstracts were identified and screened by two independent reviewers. Based on inclusion and exclusion criteria, nine studies were selected and subjected to a quality assessment. This quality control measure yielded eight studies for analysis in the systematic review. The prevalence of AA was higher in MD (1.0-10.0%) as compared to the general population (0-1.1%), and noted to be higher in patients with familial MD as compared to sporadic MD (16.9% vs 4.5%, p = 0.002). There was no evidence to suggest a difference in immunologic profiles or selected treatment regimens. The most commonly reported AA in patients with MD was rheumatoid arthritis with a mean point prevalence of 4.3%. Many studies did not standardize their diagnostic criteria and did not measure clinically meaningful outcomes.
Conclusions:
There is a low level of evidence because of the lack of RCTs and original prospective studies. However, in this systematic review, we have identified the latest point prevalence data on AA in MD, indicating AA to be more prevalent within the MD population. RCTs treating MD as a local AD will enhance our understanding of the disease, and potentially change the way we manage MD.
Insights
Autoimmune arthritis (AA) is more prevalent in patients with Ménière
Area of Science:
- Otolaryngology
- Rheumatology
- Immunology
Background:
- Ménière's disease (MD) management requires understanding its pathophysiology and comorbidities.
- The connection between autoimmune diseases (AD) and MD is not fully understood.
- Autoimmune arthritis (AA) is a specific comorbidity of interest in MD patients.
Purpose of the Study:
- To investigate the association between Ménière's disease and autoimmune diseases.
- To characterize the prevalence, distribution, clinical and laboratory findings, and outcomes of AA in MD patients.
Main Methods:
- Systematic review conducted following PRISMA guidelines.
- Searches of MEDLINE and EMBASE databases, supplemented by manual reference reviews (1947–May 2017).
- Qualitative synthesis of eight selected studies due to heterogeneity; meta-analysis was not possible.
Main Results:
- Prevalence of AA was higher in MD patients (1.0–10.0%) compared to the general population (0–1.1%).
- Familial MD showed a significantly higher prevalence of AA (16.9%) than sporadic MD (4.5%, p = 0.002).
- Rheumatoid arthritis was the most common AA in MD patients (mean prevalence 4.3%); diagnostic criteria and outcome measures were often non-standardized.
Conclusions:
- Autoimmune arthritis is more prevalent in the Ménière's disease population.
- Low level of evidence due to a lack of RCTs and prospective studies.
- Further RCTs treating MD as a local AD could improve understanding and management.