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The Patient Perspective on Radiogenomics Testing for Breast Radiation Toxicity
T Rattay1, R P Symonds1, S Shokuhi2
1Department of Cancer Studies, University of Leicester, Leicester, UK.
Clinical Oncology (Royal College of Radiologists (Great Britain))
|December 31, 2017
Summary
Patients support radiogenomics testing for breast radiation toxicity but prefer results be given to healthcare professionals. Advance knowledge of radiation toxicity risk rarely influenced treatment decisions in this study.
Area of Science:
- Oncology
- Genetics
- Radiotherapy
Background:
- Radiogenomics offers potential genetic markers for predicting individual susceptibility to radiation toxicity.
- Predictive models integrating radiogenomics are under development in the REQUITE trial.
Purpose of the Study:
- To explore breast cancer patients' attitudes towards predictive radiogenomics testing for radiation toxicity.
Main Methods:
- Semi-structured interviews were conducted with 21 breast cancer patients in the REQUITE study.
- Inductive thematic analysis was used to identify common themes in patient attitudes.
Main Results:
- Patients expressed willingness to undergo testing, emphasizing the need for information and trusted experts.
- Key themes included implications of testing (preparation, anxiety) and its impact on treatment decisions (cancer cure, breast integrity, patient preferences).
Conclusions:
- Patients generally support radiogenomics testing for breast radiation toxicity and trust its validity.
- Results suggest a preference for results to be communicated via healthcare professionals.
- Advance knowledge of toxicity risk had limited impact on treatment decisions, except in cases of severe symptoms or organ damage.
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