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Plaquing of Herpes Simplex Viruses
Published on: November 5, 2021
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Are miRNAs critical determinants in herpes simplex virus pathogenesis?
Siddheshvar Bhela1, Barry T Rouse1
1Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA.
Microbes and Infection
|December 31, 2017
Summary
MicroRNAs (miRNAs) regulate gene expression and are involved in viral infections. This review explores their role in herpes simplex virus pathogenesis and potential as biomarkers and therapeutics.
Area of Science:
- Molecular Biology
- Virology
- Genetics
Background:
- MicroRNAs (miRNAs) are key regulators of gene expression, controlling translation and mRNA degradation.
- Viruses utilize host and express their own miRNAs to manipulate cellular processes.
- Viral infections significantly alter host miRNA profiles, often promoting viral evasion and latency.
Purpose of the Study:
- To review the function of host and viral miRNAs in herpes simplex virus (HSV) pathogenesis.
- To explore the potential of miRNAs as diagnostic biomarkers for HSV infections.
- To discuss the therapeutic applications of miRNAs in managing HSV.
Main Methods:
- Literature review of studies on miRNA function in viral pathogenesis.
- Analysis of miRNA-host and miRNA-viral interactions.
- Evaluation of current research on miRNA-based diagnostics and therapeutics for HSV.
Main Results:
- Both host and viral miRNAs play critical roles in regulating HSV infection dynamics.
- Altered miRNA expression is a hallmark of HSV infection, influencing immune response and latency.
- Emerging evidence supports the use of specific miRNAs as potential biomarkers for HSV detection.
Conclusions:
- miRNAs are integral to the complex interplay between HSV and the host.
- Targeting viral or host miRNAs offers promising therapeutic strategies against HSV.
- Further research is needed to fully harness miRNAs for HSV diagnosis and treatment.
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