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Updated: Feb 16, 2026

Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter
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Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter

Published on: June 15, 2015

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Symptomatic partial and transitional atrioventricular septal defect repaired in infancy

Sylvia Krupickova1, Gareth J Morgan2, Mun Hong Cheang3

  • 1Department of Paediatric Cardiology, Royal Brompton Hospital, London, UK.

Heart (British Cardiac Society)
|December 31, 2017
PubMed

Insights

Infants with symptomatic atrioventricular septal defects need early surgical repair. Unfavorable left atrioventricular valve anatomy is a key risk factor for reoperation in these young patients.

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Disease Surgery
  • Pediatric Cardiac Surgery

Background:

  • Symptomatic infants with partial and transitional atrioventricular septal defects (AVSD) undergoing early surgical repair are considered high-risk.
  • The specific outcomes and risk factors for this patient group are not well-defined.

Purpose of the Study:

  • To evaluate the outcomes of symptomatic infants undergoing early surgical repair for partial and transitional AVSD.
  • To identify risk factors associated with mortality and reoperation in this cohort.

Main Methods:

  • A multicenter study involving 51 infants (0-1 year) with symptomatic partial/transitional AVSD requiring biventricular repair.
  • Data collected on patient demographics, surgical procedures, valve anatomy, and clinical outcomes including mortality and reoperation rates.

Main Results:

  • Three in-hospital deaths (5.9%) occurred post-primary repair.
  • Eleven patients (22%) required reoperation, primarily for left atrioventricular valve regurgitation/stenosis.
  • Unfavorable left atrioventricular valve anatomy was the sole predictor of reoperation (31% of patients had unfavorable anatomy).

Conclusions:

  • Early surgical repair of symptomatic partial/transitional AVSD in infants leads to significant morbidity and mortality.
  • A high reoperation rate is associated with unfavorable left atrioventricular valve anatomy in this population.
Abstract

Keywords:
congenital heart diseasecongenital heart disease surgery

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