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Myelin changes at the early stage of 5XFAD mice

Lihua Gu1, Di Wu1, Xiang Tang1

  • 1Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.

Brain Research Bulletin
|December 31, 2017
PubMed

Insights

Myelin deficits occur early in Alzheimer's disease (AD) models, appearing by 1 month of age and worsening over time. These early myelin changes correlate with cognitive impairments in the brain.

Area of Science:

  • Neuroscience
  • Neurodegenerative Diseases
  • Myelin Biology

Background:

  • Alzheimer's disease (AD) is associated with myelin deficits, but their occurrence in early stages remains unclear.
  • Investigating early-stage myelin changes is crucial for understanding AD pathogenesis.

Purpose of the Study:

  • To dynamically investigate myelin deficits in cognition-associated brain regions of 5XFAD mice at early stages of Alzheimer's disease.
  • To correlate myelin changes with spatial learning and memory deficits.

Main Methods:

  • Transmission electron microscopy (TEM) to assess myelin in specific brain regions (PrL, Rsg, CA1, ERC) at 1, 2, 3, and 5 months.
  • Morris water maze (MWM) to evaluate spatial learning and memory in 5XFAD mice.

Main Results:

  • Myelin deficits and increased g-ratio (indicating thinner myelin) were evident in 1-month-old 5XFAD mice, preceding observable changes in wild-type mice.
  • Myelin abnormalities progressed with age and affected more brain regions in 5XFAD mice.
  • Spatial memory deficits were observed from 1 month and spatial learning deficits from 2 months of age in 5XFAD mice.

Conclusions:

  • Myelin deficits are an early and progressive feature in the 5XFAD mouse model of Alzheimer's disease.
  • Sequential myelin changes occur in cognition-associated brain regions, suggesting a potential role in cognitive dysfunction.
Keywords:
5XFAD miceAlzheimer’s diseaseCognitionMyelin

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