Related Experiment Video

Updated: Feb 16, 2026

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test
08:07

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test

Published on: November 23, 2019

11.9K

TNF-related apoptosis-inducing ligand (TRAIL) as the potential therapeutic target in hematological malignancies

Adel Naimi1, Ali Akbar Movassaghpour2, Majid Farshdousti Hagh2

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 31, 2017
PubMed

Insights

TNF-related apoptosis-inducing ligand (TRAIL) shows promise for cancer therapy by selectively inducing cancer cell death. TRAIL-based treatments are being explored for hematological malignancies, offering a potential alternative to conventional therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Conventional cancer treatments like chemotherapy and radiotherapy often cause systemic toxicity and recurrence.
  • Acquired or pre-existing resistance is a significant challenge in current cancer therapies.
  • TNF-related apoptosis-inducing ligand (TRAIL) is a promising molecule due to its selective induction of apoptosis in tumor cells.

Purpose of the Study:

  • To summarize TRAIL-related therapies.
  • To evaluate TRAIL as a potential therapeutic option for hematological malignancies.

Main Methods:

  • Review of existing literature on TRAIL.
  • Analysis of studies involving recombinant TRAIL and its receptor agonists.
  • Examination of preclinical data and clinical trial results (Phase II).

Main Results:

  • TRAIL preferentially induces apoptosis in various tumor cells.
  • TRAIL spares adjacent normal cells, reducing systemic toxicity.
  • Recombinant TRAIL and receptor agonists show efficacy in cell lines and early clinical trials.

Conclusions:

  • TRAIL-based therapies represent a potential advancement in cancer treatment.
  • TRAIL offers a targeted approach with reduced side effects compared to conventional methods.
  • Further investigation of TRAIL is warranted for hematological malignancies.

More Related Videos

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.7K
Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method16:07

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

9.7K

Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
24.5K
Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
15.3K
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
15.3K
Ligand Binding Sites02:40

Ligand Binding Sites

8.9K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
5.7K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

4.2K