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Retzius-Sparing Robot-Assisted Radical Prostatectomy
Published on: May 19, 2022
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The Association Between Sarcopenia and Oncologic Outcomes After Radical Prostatectomy
Ross J Mason1, Stephen A Boorjian1, Bimal Bhindi1
1Department of Urology, Mayo Clinic, Rochester, MN.
Clinical Genitourinary Cancer
|January 1, 2018
Summary
Sarcopenia, a loss of muscle mass, was not linked to worse outcomes after radical prostatectomy for prostate cancer. This study found no significant association between sarcopenia and complications, recurrence, or mortality in these patients.
Area of Science:
- Oncology
- Geriatrics
- Surgical Outcomes
Background:
- Sarcopenia is a known risk factor for poor outcomes in various cancer surgeries.
- Its impact on outcomes following radical prostatectomy (RP) for prostate cancer requires further investigation.
Purpose of the Study:
- To determine if sarcopenia is associated with perioperative complications, biochemical recurrence (BCR), systemic progression (SP), or all-cause mortality (ACM) after RP.
Main Methods:
- Preoperative skeletal muscle indices (SMI) were calculated from CT scans of 698 patients undergoing RP.
- Patients were classified as sarcopenic based on international consensus SMI thresholds.
- Cox proportional hazards regression models were used to analyze associations between sarcopenia and outcomes.
Main Results:
- Sarcopenic patients were older but similar in other clinical/pathologic characteristics.
- No significant difference in perioperative complications was observed between sarcopenic and nonsarcopenic groups.
- Sarcopenia was not significantly associated with BCR, SP, or ACM in multivariable analysis.
Conclusions:
- Sarcopenia is not an independent predictor of adverse perioperative or oncologic outcomes after radical prostatectomy.
- The presence of sarcopenia may not be a prognostic marker for inferior outcomes in men with localized prostate cancer undergoing RP.
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