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Updated: Feb 16, 2026

Surface Properties of Synthesized Nanoporous Carbon and Silica Matrices
Published on: March 27, 2019
Modeling of a Hybrid Langmuir Adsorption Isotherm for Describing Interactions Between Drug Molecules and Silica
Thomas Sandberg1, Christian Weinberger2, Didem Şen Karaman3
1Center of Excellence in Functional Materials at Biological Interfaces, Åbo Akademi University, Porthansgatan 3-5, 20500 Åbo, Finland; Laboratory of Physical Chemistry, Åbo Akademi University, Porthansgatan 3-5, 20500 Åbo, Finland.
Abstract:
The interaction between disulfiram (Antabus®) and silica was studied experimentally by adsorption from apolar solvent onto highly porous silica material (Santa Barbara amorphous material-3) with large surface area. The adsorption isotherm was fitted to the Langmuir model by accounting 2 different affinities contributing to the overall behavior, which were attributed to 2 different types of silanol groups (i.e., geminal and vicinal) present on amorphous silica surfaces. This assumption was supported by theoretical calculations. In addition, the model could describe the adsorption of ibuprofen to the carrier material, indicating that the model bears big potential for describing the interactions between silica surfaces and drug molecules.
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