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Updated: Feb 16, 2026

A High-throughput Automated Platform for the Development of Manufacturing Cell Lines for Protein Therapeutics
Published on: September 22, 2011
Continuous integrated manufacturing of therapeutic proteins
Daniel Johannes Karst1, Fabian Steinebach1, Massimo Morbidelli1
1Institute for Chemical and Bioengineering, Department for Chemistry and Applied Biosciences, ETH Zurich, Switzerland.
Abstract:
With the growth of our understanding of biopharmaceutical processes, a transition from classical batch to continuous integrated manufacturing of therapeutic proteins is taking place across laboratory, clinical and commercial scales. Encouraged by regulatory authorities, this transition is favoured by new emerging technologies as well as by the development of better simulation models. The current status of continuous cell culture and downstream processes and requirements for their successful integration are discussed in this article, with specific reference to product quality attributes.
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