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N-substituted methyl maleamates as larvicidal compounds against Aedes aegypti (Diptera: Culicidae)

Laura Harburguer1, Paula V Gonzalez2, Paola Gonzalez Audino2,3

  • 1Centro de Investigaciones de Plagas e Insecticidas (CIPEIN-UNIDEF/CITEDEF/CONICET), J.B. de LaSalle 4397, Villa Martelli, 1603, Buenos Aires, Argentina. lharburguer@citedef.gob.ar.

Parasitology Research
|January 1, 2018
PubMed

Insights

New N-substituted methyl maleamates show promise as larvicides against the Aedes aegypti mosquito. These compounds offer a potential alternative to traditional insecticides, combating insecticide resistance in mosquito populations.

Area of Science:

  • Medical Entomology
  • Insecticide Development
  • Public Health

Background:

  • Arboviral diseases like dengue and Zika are transmitted by Aedes aegypti mosquitoes.
  • Larvicides are crucial for mosquito control, but insecticide resistance is a growing problem.
  • Novel larvicides are needed to manage insecticide-resistant Aedes aegypti populations.

Purpose of the Study:

  • To evaluate the larvicidal efficacy of three N-substituted methyl maleamates against Aedes aegypti.
  • To determine if these compounds offer a new mode of action for mosquito control.

Main Methods:

  • Testing N-propyl methyl maleamate (PMM), N-butyl methyl maleamate (BMM), and N-hexyl methyl maleamate (HMM) as larvicides.
  • Assessing larva mortality after 1 and 24 hours of exposure.
  • Calculating LC50 and LC95 values for efficacy determination.

Main Results:

  • N-substituted methyl maleamates demonstrated rapid insecticidal properties, causing mortality within 60 minutes.
  • N-hexyl methyl maleamate (HMM) exhibited higher efficacy, with LC50 values of 0.7 ppm (1h) and 0.3 ppm (24h).
  • LC95 values for HMM were 11 ppm (1h) and 3 ppm (24h), indicating significant larvicidal activity.

Conclusions:

  • N-substituted methyl maleamates possess insecticidal activity against Aedes aegypti larvae.
  • These compounds represent potential alternatives to conventional larvicides.
  • Further research into their mechanism of action and non-target toxicity is warranted.
Keywords:
Aedes aegyptiLarvaeLarvicideMaleamates

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