The Prognostic Value of Heart-Type Fatty Acid Binding Protein in Patients with Acute Coronary Syndrome
Wang Hai-Long1, Pang Xiao-Hua1, Yang Jian-Jun1
1Department of Cardiology, Chongqing Three Gorges Central Hospital, Chongqing, China.
Insights
Heart-type fatty acid binding protein (H-FABP) positivity indicates a poorer prognosis for acute coronary syndrome (ACS) patients, with increased mortality and cardiac events. Myocardial infarction rates did not significantly differ, requiring further research.
Area of Science:
- Cardiology
- Biomarkers
- Clinical Prognostics
Background:
- Prognostic value of heart-type fatty acid binding protein (H-FABP) in acute coronary syndrome (ACS) is not well-defined.
- H-FABP is a potential biomarker for myocardial injury and cardiac stress.
Purpose of the Study:
- To evaluate the association between H-FABP levels and patient outcomes in acute coronary syndrome (ACS).
- To determine if H-FABP status impacts mortality and cardiac event rates in ACS patients.
Main Methods:
- Systematic literature search of EMBASE, PubMed, Cochrane Library, and Medline databases up to June 2017.
- Meta-analysis of four studies including 1,994 patients (554 H-FABP positive, 1,440 H-FABP negative).
- Pooled odds ratios, heterogeneity, quality, and publication bias analyses were performed.
Main Results:
- H-FABP positive patients showed significantly higher incidence of mortality (OR, 6.39; p<0.01) and cardiac events (OR, 3.94; P<0.01).
- No significant difference in myocardial infarction (MI) incidence was observed (OR, 1.43; P=0.32).
- Limited data from randomized studies may explain the non-significant MI finding.
Conclusions:
- Positive H-FABP status is linked to increased mortality and cardiac events in ACS patients.
- Further large-scale randomized controlled trials are necessary to confirm these findings, particularly regarding myocardial infarction.
- H-FABP may serve as a valuable prognostic biomarker in acute coronary syndrome management.
Abstract:
The effect of heart-type fatty acid binding protein (H-FABP) remains unclear on the quality of the prognoses of patients with acute coronary syndrome (ACS). The authors searched the EMBASE, PubMed, Cochrane Library, and Medline electronic databases from their respective inceptions throughout June 2017. Odds ratios were pooled from individual studies, and conducted heterogeneity analysis, quality assessment, and publication bias analysis. A total of four studies with 1,994 patients were included (554 positive patients; 1,440 negative patients). Pooled analysis of these studies showed that patients positive for H-FABP had higher incidence for mortality (OR, 6.39; p<0.01) and cardiac events (OR, 3.94; P<0.01) than negative patients, but myocardial infarction (MI) (OR, 1.43; P=0.32) showed no significant differences. ACS patients positive for H-FABP had higher rates in cardiac events and mortality. The incidence of MI showed no significant difference, possibly because this study was based on limited data from randomized studies. Additional substantial randomized controlled trials certainly needed to verify these discovery.
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