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Updated: Feb 16, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
Surgical and medical antibiotic prophylaxis
H Haas1, E Launay2, P Minodier3
1Urgences pédiatriques, Fondation Lenval, Nice, France; Groupe de Pathologie Infectieuse Pédiatrique de la Société Française de Pédiatrie, Saint-Maur des Fossés, France.
Abstract:
Surgical site infections are the leading cause of perioperative morbidity and mortality as well as increased costs following surgery. Among preventive measures, antibiotic prophylaxis, when indicated, significantly decreases these risks. Adult and pediatric guidelines have recently been published (1,2). Specific pediatric data are scarce, but adult recommendations can be used by extrapolation except for neonates. For procedures that may warrant antimicrobial prophylaxis, agents of choice are frequently first-generation cephalosporins such as cefazolin, that are not currently used in curative treatment, with an appropriate dosage. Administration of an antimicrobial agent within 1 hour before surgery is often sufficient. Continuation for more than 24 hours is exceptionally advised.
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