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Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
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The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Growth of Cartilage and Bone Tissue01:27

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
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Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
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The Metabolic Microenvironment Steers Bone Tissue Regeneration.

Julia Loeffler1, Georg N Duda2, F Andrea Sass2

  • 1Julius Wolff Institute, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany; Berlin Institute of Health (BIH), 10178 Berlin, Germany.

Trends in Endocrinology and Metabolism: TEM
|January 2, 2018
PubMed
Summary

Cancer research reveals metabolic symbiosis in cells. This review explores how metabolic cooperation and reprogramming drive tissue regeneration, using bone healing as a model system.

Keywords:
bone regenerationfractureinflammationlactatemesenchymal stromal cellsmetabolism

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Area of Science:

  • Metabolic regulation in multicellular organisms.
  • Cellular metabolism and tissue repair.

Background:

  • Metabolic symbiosis aids cell survival under nutrient scarcity, a phenomenon observed in cancer research.
  • The role of metabolic cooperation and reprogramming in tissue regeneration remains under-explored.
  • Disrupted nutrient and oxygen supply in regenerating tissues mirrors conditions in tumors.

Purpose of the Study:

  • To provide a schematic overview of metabolic links driving tissue regeneration.
  • To highlight the potential of metabolic pathways in enhancing regenerative processes.
  • To use bone healing as a model system to study metabolic influences on regeneration.

Main Methods:

  • Literature review focusing on metabolic symbiosis and tissue regeneration.
  • Analysis of metabolic reprogramming in the context of cellular development and fate.
  • Case study of bone healing as a model for scar-free regeneration.

Main Results:

  • Metabolic symbiosis is crucial for cells facing high energy demands and limited nutrients.
  • Metabolic reprogramming significantly influences cellular development, fate, and function during regeneration.
  • Bone healing exemplifies a regenerative process potentially driven by specific metabolic interactions.

Conclusions:

  • Metabolic cooperation is a key factor in successful tissue regeneration.
  • Understanding metabolic links can unlock new strategies for regenerative medicine.
  • Bone regeneration serves as a valuable model for investigating metabolic drivers of tissue repair.